Mildonium (Mildronate) is a nootropic, vasodilator and CNS stimulant that can unlock your intellectual and physical potential.
This content has been written and checked for quality and accuracy. Content Administrator Updated on: 18/10/2023. Next review: 18/04/2024
Mildronium (MILDRONAT) is a structural analogue of gamma-butyrobetaine, a substance found in every cell of the human body.
Under conditions of increased stress, MILDRONAT restores the balance between cellular oxygen supply and demand, eliminates the accumulation of toxic products of metabolism in cells, protecting them from damage; it also has a tonic effect. As a result of its use, the body acquires the ability to withstand stress and quickly restore energy reserves. Thanks to these properties, MILDRONAT® is used to treat various disorders of the cardiovascular system and cerebral blood supply, as well as to improve physical and mental performance. As a result of decrease of carnitine concentration, gamma-butyrobetaine, which possesses vasodilatory properties, is intensively synthesized. In acute ischemic myocardial damage, MILDRONAT slows down the formation of the necrotic zone and shortens the rehabilitation period. In case of heart failure, it increases myocardial contractility, increases exercise tolerance, reduces the frequency of angina attacks. In acute and chronic ischemic cerebral circulatory disorders MILDRONAT improves blood circulation in ischemic area, promotes blood redistribution in favor of ischemic area. The drug eliminates functional disorders of the nervous system in patients with chronic alcoholism in withdrawal syndrome.
Cardioprotective agent normalizing myocardial metabolism and vasodilator properties.
Bioavailability of the drug after intravenous administration is 100%. Maximum concentration in blood plasma is reached immediately after administration. The drug is metabolized in the body to form two main metabolites, which are eliminated by the kidneys. The elimination half-life (T1/2) is 3 to 6 hours.
The safety of using Mildronate during pregnancy has not been proved.
To avoid possible adverse effects on the fetus, the drug should not be prescribed during pregnancy.
It is unknown whether the drug is excreted with breast milk.
If it is necessary to use Mildronate during lactation, breastfeeding should be stopped.
Hypersensitivity to the components of the drug, increased intracranial pressure (with venous outflow disorders, intracranial tumors), age under 18 years (effectiveness and safety have not been established), pregnancy, lactation.
Depending on the frequency of occurrence, the following groups of adverse reactions are distinguished by the WHO: very common (>1/10), common (>1/100, < 1/10), infrequent (>1/1000, < 1/100), rare (>1/10000, < 1/1000), very rare (< 1/10000), including some reports, frequency unknown – cannot be determined by available data.
Rare allergic reactions (redness, rashes, itching, edema), as well as dyspeptic complaints, tachycardia, decreased or increased blood pressure, agitation.Very rare – eosinophilia, general weakness.
When used together Mildronate increases the effect of antianginal drugs, some hypotensive drugs, cardiac glycosides.
Mildronate can be combined with antianginal agents, anticoagulants and antiaggregants, antiarrhythmic agents, diuretics, bronchodilators.
When combining nitroglycerin, nifedipine, alpha-adrenoblockers, hypotensive drugs and peripheral vasodilators with Mildronate, moderate tachycardia and arterial hypotension may develop (caution should be exercised when using this combination).
Due to possible development of excitatory effect, it is recommended to use in the morning.
Mildronate is administered intramuscularly (i.m.), intravenously (i.v.) and parabulbar. Mode of administration, doses and duration of treatment are determined individually depending on indications, severity of the condition, etc.
As part of the complex therapy:
Mildronat 0.5 g (5 ml of the preparation) 1 time a day v/v for 10 days as a part of complex therapy in acute phase, afterwards transferring to oral intake of 0.5 1 g. Total course of treatment is 4-6 weeks.
In chronic insufficiency of cerebral circulation (discirculatory encephalopathy) 0.5 g (5 ml of the preparation MILDRONAT) once a day during 10 days, then 0.5 g – orally. Total course of treatment is 4 6 weeks.
Repeated courses (usually 2-3 times a year) are possible after consultation with a physician.
Hemophthalmia and retinal hemorrhages of various etiology, central retinal vein thrombosis and its branches, retinopathies of various etiology (diabetic, hypertensive)).
0.05 g (0.5 ml of the drug MILDRONAT) parabulbar for 10 days. It is also used as part of combined therapy.
0.5 g (5 ml of MILDRONAT) i/m or i.v. once a day. The course of treatment is 10-14 days. If necessary the treatment is repeated after 2-3 weeks.
0.5 g (5 ml of the drug MILDRONAT®) i/m or i.v. 2 times a day. The course of treatment is 7 10 days.
Symptoms: decreased blood pressure, accompanied by headache, tachycardia, dizziness and general weakness.
Treatment: symptomatic.
Mildronate is mildly toxic and does not cause adverse reactions dangerous to the health of patients.
Mildonium (Mildronate) is a nootropic, vasodilator and CNS stimulant that can unlock your intellectual and physical potential.
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